龈沟液是从牙龈结缔组织内透过龈沟内上皮和结合上皮渗入到龈沟内的液体。目前学术界认为龈沟液可以反映牙周支持组织的代谢变化，其水平检测是评价牙周炎症程度的一个敏感指标。但牙周炎过程中龈沟液的成分较复杂，其中包含各种酶、参加牙周破坏的其他因子及细胞和组织降解产物。该文对牙周炎龈沟液中的部分生物标志物予以综述。“,”Gingival crevicular fluid(GCF) is an inflammatory exudate infiltrated from the gingival con-nective tissue into gingival sulcus through the sulcular epithelium and junctional epithelium .At present, the scholars think that GCF could reflect the metabolism of periodontal supporting tissue , the level detection of which is a sensitive index for evaluating the degree of periodontal inflammation .But during periodontitis,the elements of GCF are complex,which contains various enzymes,other factors involved in periodontal destruc-tion and degradation products of cells and tissues .Here is to make a review of the current GCF biomarkers of periodontitis.