采用高速毛细管电泳安培法对人工合成雌激素———己烯雌酚 (DES)的测定进行了研究 ;通过优化选择检测电位、毛细管内径和长度、分离电压、缓冲溶液等实验参数 ,DES在60s内可以得到较好的分离 ,检出限为1.0×10 -8mol/L ,DEC浓度在1.48×10 -4～3.69×10 -5mol/L ,1.25×10 -6～1.85×10 -7mol/L与峰面积分段呈良好的线性关系 ;迁移时间和峰面积的相对标准偏差分别为0.65 %、2.2 % ;将该法用于市售肉类中DES的检测 ,取得了满意的结果 The determination of synthetic estrogen, diethylstilbestrol (DES), was studied by high performance capillary electrophoresis amperometry. DES was obtained in 60s by optimizing the selection of detection potential, capillary inner diameter and length, separation of voltage and buffer solution, The detection limit was 1.0 × 10 -8 mol / L and the concentration of DEC was 1.48 × 10 -4 ~3.69 × 10 -5 mol / L and 1.25 × 10 -6 ~ 1.85 × 10 -7 mol / L with the peak area And the relative standard deviation of migration time and peak area were 0.65% and 2.2%, respectively. The method was applied to the detection of DES in commercial meat and the satisfactory results were obtained