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为更好地研究高分解代谢型急性肾功能衰竭 ,建立了此疾病的动物模型。SD大鼠分成A、B、C三组 ,分别建立败血症模型、急性缺血性肾功能衰竭模型和高分解代谢型急性肾功能衰竭模型。败血症模型由腹腔中注入大肠杆菌而制成 ;急性缺血性肾衰模型采用一侧肾切除及对侧肾动脉夹闭 60min而制成 ;高分解代谢急性肾衰模型则在造成大鼠急性肾衰同时 ,从腹腔中注入大肠杆菌而制成。结果表明 ,高分解代谢急性肾衰鼠在术后出现败血症的临床表现 ,且与败血症和急肾衰组相比 ,前者的血尿素氮、肌酐和血钾在术后明显增高 ,而二氧化碳结合力和体重明显下降 ,死亡率也较高 ,这符合高分解代谢急性肾衰的临床特点 ,表明所建立的高分解代谢急性肾衰模型是成功的
In order to better study the acute catabolic renal failure, an animal model of this disease was established. Sprague-Dawley rats were divided into three groups: A, B and C, respectively, to establish sepsis model, acute ischemic renal failure model and acute renal failure model with high catabolism. Sepsis model was made by intraperitoneal injection of Escherichia coli; acute ischemic renal failure model with one side of the nephrectomy and contralateral renal artery occlusion 60min made; acute catabolic model of acute renal failure in rats caused by acute kidney At the same time, from the abdominal cavity into E. coli and made. The results showed that the acute catabolism of acute renal failure rats after sepsis clinical manifestations, and compared with sepsis and acute renal failure group, the former significantly increased blood urea nitrogen, creatinine and potassium after surgery, and carbon dioxide binding And significantly decreased body weight and higher mortality, which is consistent with the clinical features of acute renal failure with high catabolism, indicating that the model of acute renal failure with high catabolism is successful