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小鼠模型广泛应用于食品科学、毒理学及相关学科。为提供ICR小鼠和BalB c的背景 ,本研究考察了 10项免疫指标治疗。选用ICR小鼠、BalB c小鼠各 6 0只 ,按《保健食品功能学评价程序和检验方法》进行试验。在迟发型变态反应 (DTH)、半数溶血值、巨噬细胞鸡红细胞吞噬率、NK细胞活性 4项指标中 ,BalB c小鼠显著优于ICR小鼠 ,揭示在这 4项实验中BalB c小鼠应为首选。在脾脏体重比值、ConA刺激的小鼠淋巴细胞转化、单核 -巨噬细胞碳廓清能力、巨噬细胞鸡红细胞吞噬指数 4项指标中 ,两种小鼠差异没有显著性 ,因此在这 4项实验中ICR小鼠可以替代BalB c小鼠。另外 ,在胸腺体重比值、小鼠的抗体生成细胞数两项指标中 ,ICR小鼠的表现优于BalB c小鼠 ,其机理还不明了 ,有待进一步研究。
Mouse models are widely used in food science, toxicology and related disciplines. To provide a background on ICR mice and BalB c, this study examined 10 immune-index treatments. 60 ICR mice and 60 BalB c mice were selected and tested according to the functional food health functional assessment procedure and test method. Balb c mice were significantly better than ICR mice in delayed-type allergic reaction (DTH), hemolytic half-value, phagocytic rate of erythrocytes in macrophages and NK cell activity, revealing that in these 4 experiments, BalBc was small Mice should be preferred. There was no significant difference between the four mice in the four indicators of body weight ratio, ConA-stimulated mouse lymphocyte transformation, monocyte-macrophage carbon clearance ability, and phagocytic index of macrophage chick erythrocytes. In experiments, ICR mice can replace BalB c mice. In addition, in the thymus weight ratio, the number of antibody-producing cells in mice two indicators, ICR mice outperformed BalB c mice, the mechanism is unknown, pending further study.