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为阐明难治性心衰,对速尿的耐药机理及有效性进行了探讨。作者搜集对速尿反应良好的有效组9例,耐药组9例,共18例的心脏病患者。早晨空腹时取速尿40毫克静注,注射后6小时测定速尿在血中、尿中的浓度和速尿的肾清除率(FCLR),以及尿量、尿中电解质。并对速尿耐药组的7例,并用肼苯哒嗪,每公斤体重0.2毫克静注,比较注射前后的效果。
In order to elucidate refractory heart failure, the mechanism and effectiveness of furosemide resistance were discussed. The authors collected effective response to furosemide effective group of 9 patients, drug-resistant group of 9 patients, a total of 18 patients with heart disease. In the morning fasting take 40 mg of furosemide intravenously, measuring furosemide 6 hours after injection in the blood, urine concentration and furosemide renal clearance (FCLR), and urine output, urine electrolytes. In addition, 7 cases were treated with furosemide, and hydralazine 0.2 mg per kilogram of body weight was injected intravenously to compare the effect before and after injection.