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目的观察颈动脉粥样硬化(AS)斑块内纤溶酶原激活抑制物-1(PAI-1)的mRNA和抗原的表达情况。方法分别应用原位杂交和免疫组织化学测定颈AS斑块内PAI-1mRNA和抗原表达。结果相对于正常动脉内膜,颈AS病变内膜PAI-1阳性细胞数明显增多(P<0.05),其中颈AS严重病变肩区阳性细胞数最多,且以单核-巨噬细胞为主。结论PAI-1与颈AS发生有关。
Objective To observe the expression of plasminogen activator inhibitor - 1 (PAI-1) mRNA and antigen in carotid atherosclerosis (AS) plaque. Methods The expression of PAI-1 mRNA and antigen in cervical AS plaques were detected by in situ hybridization and immunohistochemistry respectively. Results Compared with normal intima, the number of PAI-1 positive cells in the neck AS lesions was significantly increased (P <0.05). The number of PAI-1 positive cells in the neck AS lesions was the most, with monocyte-macrophage predominance. Conclusion PAI-1 is related to the occurrence of neck AS.