论文部分内容阅读
目的:研究双次核电磁脉冲(NEMP)照射对大鼠学习记忆能力的影响.方法:先用Y迷宫训练照射组(n=6)和对照组(n=6)大鼠,使之形成条件反射,以形成条件反射时每只鼠跑迷宫总次数(MT)、条件反射形成次数(CT)、分辨学习成绩(RS)、条件反射百分比(PC)等为指标,记录每只大鼠原有学习记忆能力,之后用NEMP模拟器重复两次全身照射照射组大鼠,两组(实验组与对照组)分别于照后24,48和72h测试学习记忆能力.结果:照射组和对照组的MT和PC在照后的3个时间点均与照前相比有显著差异(P<0.05),两组对应时间点之间相比未见显著差异(P>0.05),但在照射组照后72h与照后24h相比MT明显减少(P<0.05);对照组CT仅在24h时间点和照前有显著差别(P<0.05),照射组CT24h时间点与照射前相比未见显著差异(P>0.05),但48h和72h时间点与照前相比有显著差异(P<0.05),各对应时间点之间亦未见显著差异;对照组和照射组RS在24,48,72h时间点与照射前有显著差别(P<0.05),各对应时间点之间未见显著差异(P>0.05).结论:重复两次NEMP照射可使大鼠学习记忆力在第1日抑制,?
Objective: To study the effect of double nuclear magnetic pulse (NEMP) irradiation on learning and memory in rats. Methods: The rats in the irradiation group (n = 6) and the control group (n = 6) were trained with Y maze to make conditioned reflex to form the total number of maze maze (MT) and conditioned reflex (CT), Resolved Learning Score (RS) and Conditional Reflectance (PC) were used as indexes to record the original learning and memory abilities of each rat. After that, the rats in the whole body irradiation irradiation were repeated twice with the NEMP simulator. Two groups (Experimental group and control group) at 24, 48 and 72h after irradiation to test learning and memory ability. Results: MT and PC in irradiated group and control group were significantly different from those before irradiation (P <0.05) at 3 time points after irradiation, and there was no significant difference between the two groups at corresponding time points (P <0.05). However, the MT was significantly decreased at 72h and 24h after irradiation (P <0.05). The control group had significant difference only at 24h and before irradiation (P <0.05). 05). There was no significant difference in the CT24h time point between the two groups (P> 0.05), but there were significant differences at 48h and 72h (P <0.05) There was also no significant difference between the two groups. There was a significant difference of RS between the control group and the irradiation group at 24, 48 and 72h (P <0.05), and there was no significant difference between the corresponding time points (P> 0.05). Conclusion: Repeated NEMP irradiation can inhibit learning and memory in rats on the first day.