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Pearse(1966～1969)在研究甲状腺内分泌细胞时,发现身体内各种分泌多肽激素的细胞虽然表面上形态、部位和分泌的肽激素各不相同,但却有共同的内在联系。发现它们的细胞化学和超微结构特性有许多共同点。化学特性的主要共同点是能摄取胺类前身物质,并把它们脱羟基产生生物性胺(Amine Precursor Uptake and Decarboxylation)根据这种主要细胞化学特征命名为 APUD 细胞。把脊椎动物体内所有具有这些化学特性的细胞组成一个系统,称为 APUD 细胞系统。APUD 细胞还有其他共同化学特性,但其掌握胺的能力是最重要的。它们本身也含有生物原性胺,如儿茶酚胺或5羟色胺(5HT),或能摄取这些胺;还能摄取胺的前身物质如5羟色胺酸或 DOPA,其胞浆中的氨基酸脱酶羧能使之
Pearse (1966 ~ 1969) in the study of thyroid endocrine cells, found that the body of a variety of secreted polypeptide hormone cells, although the surface morphology, location and secretion of peptide hormones are different, but there is a common internal link. It is found that their cytochemical and ultrastructural properties have much in common. The main common features of chemical properties are the ability to take up amine precursors and dehydroxylize them to produce biogenic amines (Amine Precursor Uptake and Decarboxylation). According to this major cytochemical feature, APUD cells are named. All the cells in the vertebrate body that have these chemical properties form a system called the APUD cell system. APUD cells have other common chemical properties, but their ability to master amines is the most important. They themselves also contain biogenic amines, such as catecholamines or serotonin (5HT), or they can take up these amines; predecessors that can also take up amines, such as serotonin or DOPA, whose amino acids in the cytoplasm decarboxylase the carboxyl energy