研究发现,在中枢神经系统及外周神经系统中,免疫细胞和分子在神经病理性疼痛过程中发挥着越来越重要的作用,对传统的以神经元为中心的疼痛理论发起了挑战。神经损伤后外周的肥大细胞、中性粒细胞、巨噬细胞和T淋巴细胞等免疫细胞所产生的级联炎性反应以及胶质细胞的激活是神经病理性疼痛形成和维持的关键因素,这些免疫细胞通过释放大量炎性介质最终导致疼痛的产生。 The study found that immune cells and molecules play an increasingly important role in neuropathic pain in the central and peripheral nervous systems, challenging the traditional theory of neuron-centered pain. The inflammatory reaction of the peripheral inflammatory cells, such as mast cells, neutrophils, macrophages and T lymphocytes, and the activation of glial cells after nerve injury are the key factors in the formation and maintenance of neuropathic pain Cells eventually lead to the production of pain by releasing large amounts of inflammatory mediators.