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本文用克山病病区粮和病区加硒粮分别饲喂大白鼠15～16周,以状态3呼吸速率、状态4呼吸速率、呼吸控制率和p/o比值等指标,对比观察硒对心肌线粒体氧化磷酸化的影响。发现硒可防止由病区粮引起的心肌线粒体氧化磷酸化的损害、ADP对细胞呼吸控制功能的紊乱以及线粒体结构完整性的损害。还证明了病区粮不引起线粒体氧化和磷酸化偶联过程的异常。并从能量代谢角度探讨了克山病的可能发病机理。
In this paper, Keshan disease wards and selenium-added grain food and wounded rats were fed 15 to 16 weeks to state 3 respiratory rate, state 4 respiratory rate, respiratory rate and p / o ratio and other indicators, the comparison observed selenium Effect of myocardial mitochondrial oxidative phosphorylation. Selenium was found to prevent damage to oxidative phosphorylation of myocardial mitochondria caused by ward grain, impairment of cellular respiratory control function by ADP, and impairment of mitochondrial structural integrity. It also demonstrated that ward grain did not cause abnormalities in mitochondrial oxidative and phosphorylation coupling processes. And explored the possible pathogenesis of Keshan disease from the perspective of energy metabolism.