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作者应用抗人胃癌单克隆抗体MG7对慢性萎缩性胃炎伴不典型增生(111例)、胃息肉(52例)、疣状胃炎(64例)及胃溃疡旁粘膜(37例)进行免疫组化定位,阳性率分别为42.3％,44.2％,23.4％和37.8％.表明MG7抗原物质在上述病变组织中有不同程度的表达,阳性率按增生的类型及程度分组,组间差别非常显著(P<0.01),MG7免疫组化检查为从形态学上判定胃癌前期病变的生物学行为提供了较为客观的指标.
The authors applied immunohistochemistry with anti-human gastric cancer monoclonal antibody MG7 to chronic atrophic gastritis with atypical hyperplasia (111 cases), gastric polyps (52 cases), verrucous gastritis (64 cases), and gastric ulcer adjacent mucosa (37 cases). The positive rate was 42.3%, 44.2%, 23.4% and 37.8%, respectively. It was indicated that the MG7 antigens expressed in different degrees in the above-mentioned lesions. The positive rate was grouped according to the type and degree of hyperplasia, and the difference between groups was very significant (P <0.01), MG7 immunohistochemistry provides a more objective indicator for morphologically determining the biological behavior of precancerous lesions.