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中国科学家屠呦呦由于在发现青蒿素和治疗疟疾新型疗法上的贡献而获得了2015年诺贝尔生理或医学奖.现如今以青蒿素为先导化合物衍生得到的蒿甲醚和青蒿琥酯等青蒿素类药物是治疗疟疾唯一有效的药物.但目前市售的青蒿素仍是依靠植物黄花蒿的提取,其高效人工合成依然是合成化学领域的一个挑战.由于生物合成青蒿酸的成功实现,使得从青蒿酸到青蒿素的高效化学合成,特别是无光照化学合成工艺的开发,成为人工合成青蒿素能否工业化生产的关键所在.本文从可工业化的角度,简要综述了青蒿素化学合成的研究进展.主要讨论的内容包括青蒿素化学合成的背景、仿生合成的探索以及无光照人工合成的研究等方面,为青蒿素的合成及其相关领域的科研工作者提供一个简单明了的概括.
Chinese scientist Tu Yo Yo won the 2015 Nobel Prize in Physiology or Medicine for his contributions to discovering new treatments for artemisinin and new malaria treatments. Artemether and artesunate, now derived from artemisinin as the lead compound, Artemisinin and other artemisinin drugs are the only effective drugs for the treatment of malaria, but the artemisinin currently marketed still depends on the extraction of the plant Artemisia annua and its high efficiency of artificial synthesis is still a challenge in the field of synthetic chemistry.Because of the biosynthesis of artemisinic acid The successful implementation of artemisinin from artemisinin to make efficient chemical synthesis, especially the development of non-photochemical chemical synthesis process, artificially synthesized artemisinin can become the key to industrial production.This article from the industrial point of view, a brief The research progress of artemisinin chemical synthesis is reviewed, including the background of artemisinin chemical synthesis, the exploration of bionic synthesis and the research of non-light artificial synthesis, etc. The main contents of this paper are the synthesis of artemisinin and its related fields Workers provide a straightforward summary.