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本文应用无创伤性技术,研究两名正常志愿者在血压开玛监控下静脉滴注硝普钠的临床药效。初试结果表明用药后MBP、LVET、LYETI、SV、CI、Q—Z、TTI均下降,HR增加,提示该药对正常志愿者有降低前、后负荷,降低心肌耗氧量作用。证实硝普钠在临床作降压使用对心功能无不良反应。两名受试者在计算机控制用药时无主诉,方法安全,表明血压开玛的临床应用是有意义的,展望它对定量研究药量与效应关系,减少药物副反应及毒性提供新的手段。
In this paper, noninvasive techniques were used to study the clinical efficacy of intravenous sodium nitroprusside in two normal volunteers under the control of blood pressure. The results of the first trial showed that the levels of MBP, LVET, LYETI, SV, CI, Q-Z and TTI decreased after treatment and HR increased, suggesting that the drug has the effect of lowering the myocardial load and reducing the myocardial oxygen consumption in normal volunteers. Confirmed that sodium nitroprusside in the clinical use of antihypertensive use of heart function without adverse reactions. The two subjects did not complain when using computerized medicine, and the method was safe. It shows that the clinical application of BPH is meaningful. It is expected that it will provide a new measure to quantitatively study the relationship between dose and effect and reduce side effects and toxicity of drugs.