本文观察了硝苯吡啶(Nif)对实验性高脂血症、动脉粥样硬化家兔脂质代谢的影响。结果表明,Nif对喂饲胆固醇(Ch)家兔有显著降低血浆总胆固醇、甘油三酯、低密度脂蛋白Ch、载脂蛋白B,升高血浆高密度脂蛋白Ch(HDL-Ch)及其亚类HDL_2-Ch,减少主动脉组织Ch、epoB沉积和粥样病变面积的作用。并观察了37例高血压病伴高脂血症患者,其口服Nif治疗后其血脂变化与动物实验结果一致。Nif影响脂质代谢的机制可能与Nif能加强低密度脂蛋白(LDL)受体途径处理LDL有关。 This article investigates the effects of nifedipine (Nif) on lipid metabolism in rabbits with experimental hyperlipidemia and atherosclerosis. The results showed that Nif significantly decreased plasma total cholesterol, triglyceride, low density lipoprotein Ch, apolipoprotein B, elevated plasma high density lipoprotein Ch (HDL-Ch) and its Subclass HDL_2-Ch, to reduce the aortic tissue Ch, epoB deposition and atherosclerotic lesion area. 37 patients with hypertension and hyperlipidemia were observed. The changes of blood lipids after oral administration of Nif were consistent with the animal experiments. The mechanism by which Nif affects lipid metabolism may be related to the fact that Nif can enhance the treatment of LDL by the low-density lipoprotein (LDL) receptor pathway.