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弥漫性甲状腺肿伴甲状腺功能亢进(Graves氏病,以下简称弥漫性甲亢)是甲状腺功能亢进症中最常见的类型,其发病机理与机体免疫功能障碍有密切关系。国外不少资料表明,在多数弥漫性甲亢患者血中存在一种异常的甲状腺刺激物——甲状腺刺激免疫球蛋白(Thyroid stimulating immunoglobulin,TSI)。但国内报告很少。本文对55例弥漫性甲亢患者和15例正常人进行了血清TSI测定,探讨它在本病发病中的作用;并对TSI测定的临床意义,作初步的分析。
Diffuse goiter with hyperthyroidism (Graves’s disease, hereinafter referred to as diffuse hyperthyroidism) is the most common type of hyperthyroidism, its pathogenesis and immune dysfunction are closely related. A lot of foreign data show that there is an abnormal Thyroid stimulating immunoglobulin (Thyroid stimulating immunoglobulin, TSI) in the blood of most patients with diffuse hyperthyroidism. However, few domestic reports. In this paper, 55 patients with diffuse hyperthyroidism and 15 normal subjects were measured by serum TSI to explore its role in the pathogenesis of this disease; and the clinical significance of TSI determination for preliminary analysis.