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目的:探讨生殖免疫抗体联合检测在女性不孕不育诊断中的临床价值。方法:以浙江省肿瘤医院2012年3月-2015年6月820例确诊不孕不育女性患者及500例健康志愿者为研究对象,分别设计研究组、对照组,应用酶联免疫吸附法(ELISA)对两组患者血清抗精子抗体(AsAb)、抗内膜抗体(EmAb)、抗心磷脂抗体(AcL)阳性表达率进行统计学分析探讨。结果:研究组AsAb、EmAb、AcL阳性表达率分别为58.3%、32.8%、21.6%;对照组志愿者AsAb、EmAb、AcL阳性表达率分别为5.2%、4.8%、3.6%,两组组间对比χ2值分别为29.152、28.075、15.732(P<0.05)。结论:女性不孕不育患者血清AsAb、EmAb、AcL抗体表达水平显著高于健康人,因此,以抗体阳性表达率检测女性不孕不育临床应用价值显著。
Objective: To explore the clinical value of combined detection of reproductive immunity antibody in the diagnosis of female infertility. Methods: A total of 820 female infertility patients and 500 healthy volunteers from Zhejiang Cancer Hospital from March 2012 to June 2015 were enrolled in this study. The study groups and control groups were enrolled. Enzyme-linked immunosorbent assay (ELISA) ELISA) were used to analyze the positive expression rates of serum anti-sperm antibody (AsAb), anti-intima (EmAb) and anti-cardiolipin antibody (AcL) Results: The positive rates of AsAb, EmAb and AcL in the study group were 58.3%, 32.8% and 21.6% respectively. The positive rates of AsAb, EmAb and AcL in the control group were 5.2%, 4.8% and 3.6% The contrast χ2 values were 29.152,28.075,15.732 (P <0.05). Conclusion: The serum levels of AsAb, EmAb and AcL in female infertility patients were significantly higher than those in healthy subjects. Therefore, the value of antibody positive expression in detecting female infertility was significant.