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目的探讨结直肠癌血清中脂联素的表达,并对影响脂联素水平的因素进行分析。方法选择2010年1月至2010年6月中国医科大学附属盛京医院收治的90例结直肠癌病人作为研究组,选择30名健康成年人作为对照组。用双抗体夹心ABC-ELISA法测定血清的脂联素水平,对结直肠癌不同临床病理特征下的血清脂联素水平差异进行统计分析。结果研究组血清脂联素水平(13.08±7.99)μg/mL明显低于对照组(21.92±8.76)μg/mL(P<0.01),以男性更为明显。研究组随着肿瘤TNM分期的增加,血清脂联素水平呈现进一步下降的趋势(P<0.05),肿瘤的不同部位、不同组织学分级间的血清脂联素水平没有明显差异(P>0.05)。结论结直肠癌病人血清的脂联素水平要明显低于正常健康人,且随着肿瘤分期的增加,血清脂联素水平呈现进一步下降的趋势。
Objective To investigate the expression of adiponectin in colorectal cancer serum and to analyze the factors affecting adiponectin level. Methods From January 2010 to June 2010, 90 patients with colorectal cancer who were admitted to Shengjing Hospital of China Medical University were selected as the research group and 30 healthy adults were selected as the control group. Serum adiponectin level was measured by double antibody sandwich ABC-ELISA, and the differences of serum adiponectin levels in different clinical and pathological features of colorectal cancer were statistically analyzed. Results The level of serum adiponectin (13.08 ± 7.99 μg / mL) in the study group was significantly lower than that in the control group (21.92 ± 8.76 μg / mL, P <0.01). Serum levels of adiponectin showed a trend of declining (P <0.05) with the increase of tumor TNM staging in study group. There was no significant difference in serum adiponectin levels between different histological grades of tumor (P> 0.05) . Conclusions Serum adiponectin levels in patients with colorectal cancer are significantly lower than those in normal controls. Serum levels of adiponectin are further decreased with the increase of tumor stage.