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目的探讨新疆地区急性胰腺炎患者病因学及严重度的危险因素。方法选取急性胰腺炎患者500例,分析患者性别、年龄、病因、临床分型等临床资料,以酒精性、胆源性、高脂血症性、饮食性、其他病因、多因素、特发性进行病因分组,以18~24岁、25~39岁、40~64岁、>65岁进行年龄分组。对不同性别、年龄段及严重度的病因分布情况进行分析。分析降钙素原、C反应蛋白与急性胰腺炎严重程度的关系。结果胆源性急性胰腺炎129例(25.8%),显著多于其他病因组患者(P<0.05)。胆源性病因在女性中的比例显著高于在男性中的比例(P<0.05),酒精性病因在女性中的比例显著低于在男性中的比例(P<0.05),而高脂血症性在男性和女性患者病因中均占较高比例。各年龄段病因中胆源性AP的比例均最高,与其他病因相比差异均有统计学意义(P<0.05)。MAP病因中胆源性比例最高,与其他病因相比差异有统计学意义(P<0.05),其次为特发性、其他因素;SAP病因中高脂血症性比例最高,与其他病因相比差异有统计学意义(P<0.05)。SAP患者的PCT和CRP水平均显著高于MAP患者(P<0.05)。PCT和CRP水平与Ranson评分、Balthazar CT评分、APACHEⅡ评分正相关。结论急性胰腺炎的发生与多种危险因素有关,其中胆道疾病为急性胰腺炎的主要危险因素。
Objective To explore the risk factors of etiology and severity in patients with acute pancreatitis in Xinjiang region. Methods A total of 500 patients with acute pancreatitis were selected. Clinical data such as gender, age, etiology and clinical classification were analyzed. Alcohol, biliary, hyperlipemia, diet, other etiologies, multivariate, idiopathic Etiology group, 18 to 24 years old, 25 to 39 years old, 40 to 64 years old,> 65 years old for age grouping. Etiology of different genders, age groups and severity were analyzed. Analysis of procalcitonin, C-reactive protein and the severity of acute pancreatitis. Results 129 cases of biliary acute pancreatitis (25.8%) were significantly more than those in other etiologies (P <0.05). The proportion of biliary causes was significantly higher in women than in men (P <0.05), the proportion of alcoholic causes in women was significantly lower than that in men (P <0.05), and hyperlipidemia Sex is a high proportion of the etiology of both male and female patients. The proportions of biliary AP in the etiology of all ages were the highest, with significant difference compared with other etiologies (P <0.05). MAP in the highest proportion of biliary origin, and other causes were significantly different (P <0.05), followed by idiopathic, other factors; SAP causes of hyperlipidemia in the highest proportion, compared with other causes There was statistical significance (P <0.05). The levels of PCT and CRP in SAP patients were significantly higher than those in MAP patients (P <0.05). The levels of PCT and CRP were positively correlated with Ranson score, Balthazar CT score and APACHE Ⅱ score. Conclusions The occurrence of acute pancreatitis is related to various risk factors, of which biliary disease is the main risk factor of acute pancreatitis.