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目的探讨含泮托拉唑、左氧氟沙星的三联方案治疗幽门螺杆菌的有效性和安全性。方法将102例幽门螺杆菌(Helicobacter hpylori,Hp)阳性的消化性溃疡及慢性胃炎患者随机分为克拉霉素治疗组和阿莫西林治疗组,抑酸剂选用泮托拉唑,两组联合的抗菌药均含左氧氟沙星,疗程6d。各组在治疗1周内和治疗后4～8周分别检测Hp感染情况。结果含泮托拉唑、左氧氟沙星的三联方案Hp根除率为82.35%,克拉霉素治疗组Hp根除率与阿莫西林治疗组比较无显著性差异(84.62%vs80.0%,P>0.05)。结论含泮托拉唑、左氧氟沙星联合克拉霉素或阿莫西林是安全有效的幽门螺杆菌根除方案。
Objective To investigate the efficacy and safety of triple therapy with pantoprazole and levofloxacin in the treatment of Helicobacter pylori. Methods 102 patients with Helicobacter pylori (Hp) -positive peptic ulcer and chronic gastritis were randomly divided into clarithromycin treatment group and amoxicillin treatment group, and antacid agent was selected as pantoprazole. The combination of the two groups Antibacterials contain levofloxacin, treatment 6d. Hp infection was detected in each group within 1 week of treatment and 4 to 8 weeks after treatment. Results Hp eradication rate was 82.35% in the triple regimen with pantoprazole and levofloxacin. There was no significant difference between the two groups (84.62% vs80.0%, P> 0.05). Conclusions Pantoprazole, levofloxacin combined with clarithromycin or amoxicillin is safe and effective in the treatment of H. pylori eradication.