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乙肝病毒(HBV)相关性原发性肝细胞癌(HCC)即使进行了根治性手术,肿瘤的复发率也很高。术后肿瘤的高复发是导致病人早期死亡的主要原因。术后肿瘤复发的危险因素包括病人原发肝病的严重程度、肝硬化分级、术前甲胎蛋白(AFP)水平、肿瘤的数目和大小、是否侵犯门静脉系统、是否有转移及手术切除的范围等。但对于HBV相关的HCC来说,术前HBVDNA载量及是否进行了有效的抗病毒治疗是标志病人术后存活期及无肿瘤复发生存的独立危险因素。早期、有效和规范的抗病毒治疗,既可预防肝功能衰竭,又可大大降低肿瘤术后的复发率,从而延长病人的存活期。
Hepatitis B virus (HBV) -related primary hepatocellular carcinoma (HCC) Even with radical surgery, the recurrence rate of the tumor is also high. Postoperative tumor recurrence is the leading cause of early death in patients. Risk factors for postoperative tumor recurrence include the severity of primary liver disease, grade of cirrhosis, preoperative AFP level, number and size of tumors, invasion of the portal vein system, extent of metastasis, and surgical resection . However, for HBV-related HCC, the preoperative HBVDNA load and effective antiviral therapy are independent risk factors for postoperative survival and tumor-free relapse survival. Early, effective and standardized antiviral therapy, can prevent liver failure, but also can greatly reduce the recurrence rate of tumor surgery, thereby prolonging the survival of patients.