本文从临床、免疫学、脑电图方面,对IgG治疗严重儿童癫痫的作用进行了研究。试图从客观的神经生理学资料中确定与临床变化的可能关系。报告10例癫痫患者,男女各5例,平均年龄9.9岁(4.9～15.2岁)。均患有各种神经疾病。围产期窒息/缺氧症7例,脑膜炎2例,头部外伤1例,全部患儿都有不同程度的精神迟滞。9例伴有运动障碍,一天或一周内癫痫发作都在一次以上。均表现大发作(强直痉挛性发作、无动性发作、非典型失神发作等),每例可有多种发作。脑电图(EEG)表现弥漫性非典型暴发性棘波和/或多棘波与棘波综合,和局部性或多灶性伴有或不伴继发性双侧同步弥漫性癫痫波异常。在IgG治疗前,对每例患儿的临床特征包括发作类型、频度、持续时间进行评定。并进行神经心理检查和智商测定等。对每个儿童的行为连 This article from the clinical, immunological, electroencephalogram, IgG treatment of severe epilepsy in children were studied. Trying to determine the possible relationship with clinical changes from the objective neurophysiological data. Reported 10 cases of epilepsy patients, 5 males and 5 females, mean age 9.9 years (4.9 ~ 15.2 years old). All suffer from various neurological diseases. 7 cases of perinatal asphyxia / hypoxia, 2 cases of meningitis, head trauma in 1 case, all children have different degrees of mental retardation. 9 cases with dyskinesia, seizures more than once a day or a week. All show major episodes (tonic spastic seizures, seizures, atypical seizures, etc.), each having multiple seizures. EEG showed diffuse atypical spurious spikes and / or multiple spikes and spikes integrated, and local or multifocal with or without secondary bilateral synchronous diffuse epileptic wave abnormalities. Before IgG treatment, the clinical characteristics of each child, including the type of attack, frequency, duration of assessment. And neuropsychological tests and IQ determination. Be connected to every child’s behavior