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目的探讨维生素A水平与胎儿先天性心脏病之间的关系。方法检测1325例单胎孕妇(其中1233例作为胎儿正常组,92例作为胎儿先心病组)在不同孕周的维生素A含量,分析维生素A与胎儿先天性心脏病的相关性。结果两组孕妇平均年龄差异有统计学意义在妊娠12周之内及妊娠24~26周正常胎儿组维生素A含量分别为(0.62±0.14)mg/L和(0.55±0.06)mg/L,先心病组维生素A含量分别为(0.47±0.19)mg/L和(0.36±0.12)mg/L,差异具有统计学意义,但同组不同孕周的维生素A含量无统计学意义。结论维生素A水平与胎儿先天性心脏病的发生密切相关,指导孕妇合理膳食及补充维生素可以预防该病的发生。
Objective To investigate the relationship between vitamin A level and fetal congenital heart disease. Methods The levels of vitamin A in 1325 singleton pregnant women (1233 fetuses as normal group and 92 as fetal congenital heart disease group) were detected in different gestational weeks. The correlation between vitamin A and fetal congenital heart disease was analyzed. Results The average age of two groups of pregnant women was statistically significant. The levels of vitamin A in the normal fetuses within 12 weeks of gestation and 24-26 weeks of gestation were (0.62 ± 0.14) mg / L and (0.55 ± 0.06) mg / L, respectively The levels of vitamin A in cardiopathiae group were (0.47 ± 0.19) mg / L and (0.36 ± 0.12) mg / L respectively, with statistical significance, but there was no significant difference in vitamin A content in different gestational weeks. Conclusion The level of vitamin A is closely related to the occurrence of congenital heart disease in fetuses. It can prevent the occurrence of the disease by guiding pregnant women with proper diet and vitamin supplementation.