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沙培林(Sapylin)在临床上治疗口腔鳞癌具有一定效果。本文研究了 Sapylin 对舌鳞癌细胞株(Tca8113)细胞的抑制作用机理。实验证实:Sapylin 能抑制 Tca8113细胞的 DNA 合成;Sapylin 含量为0.015KE/ml～0.00375KE/ml,其抑制率为53.8%～61.3%。含量为1.0KE/ml时,培养8天后的Tca8113细胞集落形成率为0。提示 Sapylin 有抑制舌鳞癌细胞 Tca8113的作用。
Sapylin has a certain effect in the treatment of oral squamous cell carcinoma. This paper studied the mechanism of Sapylin’s inhibition of tongue squamous cell carcinoma cell line (Tca8113). Experiments confirmed that Sapylin can inhibit the DNA synthesis of Tca8113 cells; the Sapylin content was 0.015 KE/ml to 0.00375 KE/ml, and the inhibition rate was 53.8% to 61.3%. When the content was 1.0 KE/ml, the colony formation rate of Tca8113 cells after 8 days of culture was 0. It is suggested that Sapylin can inhibit the tongue squamous cell carcinoma Tca8113.