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IL-17的表达水平在细胞之间差异很大,目前已有研究证实IL-17与肿瘤的发生及进展有密切关系。本实验通过检测结直肠癌石蜡标本组织中和癌旁组织中的白介素-17(IL-17)的含量,探讨其与疾病的关系,及其含量的变化与与结直肠癌进展的关系。采用95例结直肠癌组织石蜡标本作为实验组,90例结直肠癌旁组织石蜡标本作为对照组的方法。使用免疫组织化学方法检测其IL-17的含量。结果显示,癌旁组织中IL-17的含量低于癌组织。由此可知,IL-17及其信号通路可以促进结直肠组织向癌的进展,通过阻断IL-17信号通路可以为结直肠癌的分子靶向治疗提供新的思路。
The expression level of IL-17 varies greatly among cells. It has been confirmed that IL-17 is closely related to tumorigenesis and progression. This experiment through the detection of paraffin specimens of colorectal tissue and para-cancer tissue interleukin-17 (IL-17) content, to explore its relationship with the disease, and its content and the relationship with the progress of colorectal cancer. 95 cases of colorectal cancer tissue paraffin specimens as the experimental group, 90 cases of colorectal cancer paraffin tissue specimens as a control group. The content of IL-17 was detected by immunohistochemistry. The results showed that the content of IL-17 in paracancerous tissues was lower than that in cancer tissues. Thus, IL-17 and its signaling pathway can promote the progression of colorectal cancer to cancer, blocking the IL-17 signaling pathway can provide new ideas for the molecular targeted therapy of colorectal cancer.