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目的调查山西省吕梁市HBV的基因型及亚型分布,并比较C基因亚型在吕梁与云南省大理市的分布差异及临床意义。方法采用PCR-PFLP法进行基因型及亚型检测。结果吕梁市HBV感染者中,B基因型11例,均为Ba亚型,占15.7%;C基因型57例,占81.4%,除2例未分型外均为Ce亚型;D基因型2例,占2.9%。25例大理市HBV C基因型感染者中,Ce 3例,Cs 21例,未分型1例;C基因亚型在两地的分布差异具有统计学意义(P<0.001);与Cs亚型相比,Ce亚型病毒感染者的HBeA阳性率有升高的趋势,但无统计学差异。结论吕梁市HBV基因型以C(Ce)型为主,HBV C基因亚型分布在中国南北两地存在明显差异,其临床相关性仍有待进一步研究。
Objective To investigate the genotypes and subtypes of HBV in Luliang City, Shanxi Province and to compare the distribution and clinical significance of C subtypes between Luliang and Dali, Yunnan Province. Methods PCR-PFLP was used to detect genotypes and subtypes. Results Among the HBV-infected patients in Luliang City, 11 cases of B genotype were Ba subtype, accounting for 15.7%; 57 cases of C genotype (81.4%), except for 2 cases of non-subtype genotype D; genotype D 2 cases, accounting for 2.9%. Among 25 cases of HBV C genotypes in Dali City, there were 3 cases of Ce, 21 cases of Cs and 1 case of undifferentiated type. The distribution of C gene subtypes was statistically different between the two groups (P <0.001) Compared with the subtype of hepatitis C virus, the positive rate of HBeA is increasing, but there is no statistical difference. Conclusion The genotypes of C (Ce) are predominant in Lvliang City. The distribution of HBV C subtypes is obviously different between North and South of China. The clinical relevance remains to be further studied.