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目的研究大鼠鞘内与脑室内注射尿激酶两种纤溶治疗对脑室系统血凝块的影响。方法借助大鼠脑立体定位仪建立大鼠脑室出血模型;测定脑组织含水量,并比较不同途径纤溶治疗对脑组织水肿的影响;通过脑片及HE染色观察血凝块清除情况。结果两治疗组鞘内组和脑室组脑组织含水量较模型组明显减少(P<0.05),但鞘内组和脑室组之间脑组织含水量无显著性差异(P>0.05);脑片及HE染色观察到模型大鼠脑室系统内血凝块有残留,而两治疗组脑室血块大部分被清除。结论脑室出血后经鞘内和脑室内纤溶治疗均能加快血块溶解,促进脑脊液循环,减轻脑组织水肿和损伤。
Objective To study the effects of two fibrinolytic therapy of intrathecal and intraventricular injection of urokinase on the clot in the ventricular system in rats. Methods Rat ventricular hemorrhage model was established by means of rat brain stereotaxic apparatus. The water content of brain tissue was measured. The effect of fibrinolytic therapy on edema of brain tissue was compared. Brain clearance and HE staining were used to observe the clot removal. Results The water content of brain tissue in intrathecal and ventricular groups in both treatment groups was significantly lower than that in model group (P <0.05), but there was no significant difference in brain water content between intrathecal and intraventricular groups (P> 0.05) Hematoxylin and eosin (HE) staining showed that there was residual blood clot in the ventricular system in model rats, while most of the blood clots in the two treatment groups were eliminated. Conclusion Intraventricular and intracerebral fibrinolytic therapy can accelerate clot lysis, promote cerebrospinal fluid circulation and edema and damage brain tissue after intraventricular hemorrhage.