心房肽(1-28)是心钠素类活性多肽的一个主要组分。它最近由De Bold从大鼠心房中分离提取出来,具有强大的利尿、利钠作用。但它对循环系统功能的影响,目前尚未见报道。本实验采用麻醉大鼠,经右颈总动脉插管,描记动脉血压,用电磁流量计置主动脉根部记录心输出量。静脉注入心房肽(1-28)20μg,对照组注入同体积的生理盐水,记录给药后即刻2、5、8、10、13、 Atrial peptide (1-28) is a major component of atrial natriuretic peptides. It was recently isolated and extracted from the rat atrium by De Bold, with a powerful diuretic and sodium action. But its impact on circulatory system function has not been reported yet. In this study, anesthetized rats were intubated through the right common carotid artery and arterial blood pressure was recorded. The cardiac output of the aortic root was recorded by electromagnetic flowmeter. Atrial natriuretic peptide (1-28) 20μg was intravenously injected into the control group, and the same volume of normal saline was injected into the control group. Immediately after the administration, 2,5,8,10,13,