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目的研究血小板活化因子(PAF)与年龄及其动脉粥样硬化性脑梗死的关系。方法研究对象分别来自保健科健康普查、体检普通人群和脑梗死住院病人。采用放射免疫法检测普通人群不同年龄段组(20~29,30~39,40~49,50~59,60~69,70~79岁共6组),和动脉粥样硬化性脑梗死组(60~69岁)的血浆PAF水平。结果普通人群随着年龄的增加,血浆PAF水平呈现增高趋势,与年龄呈显著正相关(r=03348,P<001);在40~49岁年龄段组血浆PAF水平(388±128)pg/ml已显著高于20~29年龄段组(338±96)pg/ml,P=0034。动脉粥样硬化性脑梗死组血浆PAF值显著高于普通人群60~69同年龄段组〔(504±108)pg/mlvs(433±103)pg/ml,P=0007〕。结论血PAF水平随年龄增加而升高,高血PAF可能是动脉粥样硬化性脑梗死的危险因素之一。
Objective To study the relationship between platelet activating factor (PAF) and age and atherosclerotic cerebral infarction. Methods The subjects were from Health Health Survey, physical examination of general population and in-patients with cerebral infarction. Radioimmunoassay was used to detect the common age groups (20 ~ 29, 30 ~ 39, 40 ~ 49, 50 ~ 59, 60 ~ 69 and 70 ~ 79 years old in 6 groups), and atherosclerotic cerebral infarction (60 to 69 years old) plasma PAF levels. Results The PAF level in the general population increased with age, but positively correlated with the age (r = 03348, P <001). The levels of plasma PAF in the 40-49 age group were 388 ± 128 pg / ml was significantly higher than that in the 20-29 age group (338 ± 96) pg / ml, P = 0034. Plasma PAF levels in patients with atherosclerotic cerebral infarction were significantly higher than those in the same age group of 60 to 69 (504 ± 108 pg / ml vs 433 ± 103 pg / ml, P = 0007). Conclusions Blood PAF levels increase with age, and high serum PAF may be one of the risk factors for atherosclerotic cerebral infarction.