论文部分内容阅读
目的:系统评价红花注射剂联合西医常规治疗急性脑梗死的临床疗效及安全性。方法:系统检索Embase、PubMed、the Cochrane Library、中国期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(Sino Med)、万方数据库1979~2016年文献,全面搜集红花注射剂联合西医常规治疗急性脑梗死的随机对照试验,对纳入文献进行质量评价,提取资料并通过RevMan 5.3软件进行数据分析。结果:共纳入10篇文献,累计897例受试者。Meta分析结果显示:在常规用药的基础上,联合使用红花注射剂,可提高临床总有效率(RR=1.19,95%CI:1.08~1.32,P<0.000 7)。此外,血栓通注射剂还可降低血液流变学指标等,但不能明显改善神经功能缺损评分。结论:在西医常规治疗的基础上联合使用红花注射剂对急性脑梗死有较好的疗效,其安全性仍需进一步探讨,但本研究结论还需要进一步大样本严格的随机对照试验来证实。
Objective: To systematically evaluate the clinical efficacy and safety of safflower injection in combination with Western routine treatment of acute cerebral infarction. Methods: The databases of Embase, PubMed, the Cochrane Library, Chinese Journal Full-text Database (CNKI), Chinese Science and Technology Periodical Full-text Database (VIP), Chinese Medicament Database (Sino Med) and Wanfang Database from 1979 to 2016 were systematically searched. Randomized controlled trials of safflower injection and western medicine in the treatment of acute cerebral infarction were conducted to evaluate the quality of the included literature and data were extracted and analyzed by RevMan 5.3 software. Results: A total of 10 articles were included, accumulating 897 subjects. The results of Meta analysis showed that the combination of safflor injection on the basis of routine medication could improve the total effective rate (RR = 1.19, 95% CI: 1.08-1.32, P <0.0007). In addition, Xueshuantong injection can also reduce blood rheology indicators, but can not significantly improve the neurological deficit score. Conclusion: The combination of safflower injection and traditional Chinese medicine on the basis of conventional treatment has a good curative effect on acute cerebral infarction. The safety of the safflower injection is still needed to be further explored. However, the results of this study still need further large randomized controlled trials to confirm.