论文部分内容阅读
目的:观察核黄素对中、小面积烧伤浅Ⅱ°、深Ⅱ°创面的治疗效果,并评价其药物不良反应。方法:选择160例浅Ⅱ°和80例深Ⅱ°中、小面积烧伤患者,将患者创面治疗分为核黄素组和磺胺嘧啶银(SD-Ag)组,观察各组创面完全愈合时间;指定时间创面愈合率;创面细菌培养情况;核黄素用于创面的疗效和安全性及对创面的刺激性等。结果:浅Ⅱ°创面:核黄素组完全愈合时间为(9.3±2.8)d,(SD-Ag)组为(11.0±3.5)d,P<0.01;用药后7d创面愈合率分别为(78.3±21.5)%及(64.8±23.0)%,P<0.01;深Ⅱ°创面:核黄素组完全愈合时间为(20.9±4.7)d,SD-Ag组为(23.8±6.5)d,P<0.01;用药后20d创面愈合率分别为(87.8±16.4)%及(77.6±18.5)%,P<0.01。上述数据差异均有统计学意义。同等深度烧伤创面核黄素组与SD-Ag组比较,创面均未发生感染情况,细菌学调查差异均无统计学意义(P>0.05),核黄素比SD-Ag刺激性更小。结论:核黄素是一种可用于浅Ⅱ°、深Ⅱ°中、小面积烧伤创面的有效,安全的外用药,在国内首创中、小面积烧伤创面不使用抗生素。
OBJECTIVE: To observe the effect of riboflavin in the treatment of superficial Ⅱ ° and deep Ⅱ ° wounds in moderate or small area, and to evaluate its adverse drug reactions. Methods: One hundred and sixty cases of shallow Ⅱ ° and 80 cases of deep Ⅱ ° middle and small area burn were selected. The patients were divided into riboflavin group and SD-Ag group. The complete wound healing time was observed. The wound healing rate at a given time, wound bacterial culture, the efficacy and safety of riboflavin for the wound and irritation to the wound. Results: The wound healing rate in the superficial Ⅱ ° wounds was (9.3 ± 2.8) days in the riboflavin group and (11.0 ± 3.5) days in the SD-Ag group, respectively (P <0.01) ± 21.5%, and 64.8 ± 23.0% respectively, P <0.01; for deep Ⅱ ° wound, the complete healing time was (20.9 ± 4.7) days in riboflavin group and (23.8 ± 6.5) days in SD- 0.01; wound healing rates were (87.8 ± 16.4)% and (77.6 ± 18.5)%, respectively, P <0.01 after 20 days. The above data differences were statistically significant. There was no infection in the wounds between the riboflavin group and the SD-Ag group on the same depth burn wounds, and there was no significant difference in the bacteriological survey (P> 0.05). Riboflavin was less irritating than the SD-Ag group. CONCLUSION: Riboflavin is an effective and safe topical medicine which can be used in the wounds of medium and small area Ⅱ ° Ⅱ and Ⅱ ° depth. Antibiotics are not used in the medium and small area wounds in China.