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目的:分析医院-社区-家庭健康管理对院后肾病综合征（NS）患者自我效能、生活质量的影响。方法:选取2018?年1?月至2019?年1?月在西南医科大学附属医院肾内科门诊就诊的NS患者102?例为研究对象，以随机数字表法分为对照组和干预组。对照组实施常规健康管理，干预组实施医院-社区-家庭健康管理，干预6?个月。比较两组干预前后生化指标、自我效能感及生活质量。结果:干预前两组的24 h尿蛋白、血清肌酐（Scr）、血尿素氮（BUN）、血浆白蛋白水平比较，差异均无统计学意义（n P>0.05）；干预后干预组24 h尿蛋白［（1.50±0.42）g/L比（1.90±0.61）g/L］、Scr［（152.35±20.31）μmol/L比（185.36±15.59）μmol/L］、BUN［（7.89±2.01）mmol/L比（10.32±2.35）mmol/L］均低于对照组，血浆白蛋白高于对照组［（32.35±4.48）g/L比（29.85±4.35）g/L］，差异有统计学意义（n P0.05）；干预后干预组的GSES评分为（3.00±0.56）分，高于对照组的（2.45±0.45）分，差异有统计学意义（n P0.05）；干预后干预组的健康调查问卷（SF-36）中总体健康、生理功能、躯体疼痛、精力、精神健康评分分别为（57.01±4.31）分、（70.06±5.61）分、（65.01±4.31）分、（65.41±5.40）分、（74.40±6.80）分均高于对照组的（53.10±4.60）分、（64.02±5.50）分、（61.01±4.80）分、（60.42±5.12）分、（65.42±7.12）分，差异有统计学意义（n P0.05). Levels of 24-hour urine protein, Scr and BUN were found to be significantly lower (n P<0.05) in the intervention group than the control group (1.50±0.42n vs. 1.90±0.61 g/L, 152.35±20.31 n vs. 185.36±15.59 μmol/L, 7.89±2.01 n vs. 10.32±2.35 mmol/L, respectively); however, the intervention group showed a significant increase (n P<0.05) in plasma albumin levels as compared to the control group (32.35±4.48n vs. 29.85±4.35). The intervention group reported significantly higher (n P<0.001) GSES score than the control group (3.00±0.56n vs. 2.45±0.45 points), indicating a better ability of patients in the intervention group to cope up with the daily routine activities. The post-intervention scores of the individual domains, namely overall health, physiological function, physical pain, energy, and mental health, in the SF-36 questionnaire were significantly higher (n P<0.001) in the intervention group than the control group (57.01±4.31n vs. 53.10±4.60 points, 70.06±5.61 n vs. 64.02±5.50 points, 65.01±4.31 n vs. 61.01±4.80 points, 65.41±5.40 n vs. 60.42±5.12 points, 74.40±6.80 n vs. 65.42±7.12 points, respectively), implying a better health status in the intervention group.n Conclusions:The implementation of hospital-community-family health management during the post-discharge home recuperation period of NS patients can improve their biochemical parameters and QoL, and boost their confidence in the performance of daily routine activities.