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目的:探讨不孕妇女年龄及反复宫腔内人工授精(IUI)周期次数与临床妊娠的关系。方法:回顾性总结2010年1月~2012年6月南京医科大学附属无锡妇幼保健院生殖医学中心1 164个IUI周期的临床资料,主要分析IUI周期次数及不孕妇女年龄与临床妊娠率的关系。结果:对644对不孕不育夫妇总计进行1 164个IUI周期,其中144例获得临床妊娠,平均IUI周期妊娠率为12.37%。第1次、2次、3次、4次以上组IUI周期的临床妊娠率分别为14.26%、12.75%、8.81%、7.58%,随IUI周期次数的增加,周期临床妊娠率呈显著下降的趋势。其中第1次周期组与第3次周期组及第4次周期组的平均周期临床妊娠率差异均有统计学意义(P<0.05);而且不孕妇女年龄≥35岁,IUI周期妊娠率明显降低,35岁以上不孕患者的人工授精平均周期妊娠率4.49%,第3次以上IUI临床妊娠率极端低下。结论:随着反复IUI次数的增加,临床妊娠率反而下降。年龄≥35岁女性不孕患者,2次人工授精没有妊娠,可建议尽早采用体外受精生殖技术助孕。
Objective: To investigate the relationship between infertile women’s age and the number of repeated intrauterine insemination (IUI) cycles and clinical pregnancy. Methods: The clinical data of 1 164 cycles of IUI in Reproductive Medicine Center of Wuxi Maternal and Child Health Hospital Affiliated to Nanjing Medical University from January 2010 to June 2012 were retrospectively reviewed. The relationship between the number of IUI cycles, the age of infertile women and the clinical pregnancy rate was analyzed . Results: A total of 1 164 cycles of IUI were performed on 644 infertile couples, of whom 144 were clinically pregnant with an average IUI pregnancy rate of 12.37%. The clinical pregnancy rates of the first, second, third, and fourth groups of IUI cycles were 14.26%, 12.75%, 8.81% and 7.58%, respectively. The clinical pregnancy rate decreased significantly with the increase of the number of IUI cycles . Among them, the average clinical pregnancy rates of the first cycle group, the third cycle group and the fourth cycle group were all significantly different (P <0.05), and the infertile women were 35 years or older and the IUI cycle pregnancy rate was significantly higher Reduce the average pregnancy rate of 4.49% of the artificial insemination in infertility patients over the age of 35, the third and above IUI clinical pregnancy rate is extremely low. Conclusion: With the increase of the number of repeated IUI, clinical pregnancy rate decreased. Female infertility ≥35 years of age, two inseminations without pregnancy, may be recommended as soon as possible by in vitro fertilization reproductive technology to help pregnant.