出血是浆细胞病患者相对少见的并发症,获得性血管性血友病综合征和获得性凝血障碍是出血的主要原因,治疗较困难。沙利度胺和来那度胺用于多发性骨髓瘤的治疗明显提高了治疗效果,但治疗过程中静脉血栓事件的发生率明显增高,其发病机理和预防措施是目前的研究热点。本文介绍浆细胞病患者出血和血栓并发症的发病机理和处理措施。 Bleeding is a relatively rare complication of plasma cell disease, and acquired von Willebrand syndrome and acquired coagulation disorder are the major causes of bleeding and are more difficult to treat. Thalidomide and lenalidomide for the treatment of multiple myeloma significantly improved the therapeutic effect, but the incidence of venous thrombosis during treatment was significantly increased, the pathogenesis and preventive measures is the current research focus. This article describes the pathogenesis and treatment of bleeding and thrombotic complications in patients with plasma cell disease.