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目的:了解本院HIV感染合并肾病患者载脂蛋白L1（APOL1）基因突变情况，探讨其与HIV感染患者合并肾病的相关性。方法:检测8例HIV合并肾病患者肾活检组织的APOL1基因调控区和7号外显子，了解APOL1基因突变情况及其与HIV感染合并肾病的相关性。结果:4例APOL1基因调控区检出A（-565）G突变，2例APOL1基因调控区检出T（-1157）C突变、G（-1024）T突变以及A（-765）C突变，3例APOL1基因7号外显子检出G496A突变、C702A突变、G732A突变、G812A突变、G1008A突变。结论:本院HIV感染合并肾病患者缺乏HIVAN患者APOL1基因中的G1和G2突变，8例患者均检出其他类型突变，但这些突变与具体病理类型之间的关系仍待进一步研究。“,”Objective:To investigate the apolipoprotein L1 (APOL1) gene mutation in HIV-infected patients with nephropathy in our hospital, and its correlation with the comorbid nephropathy in HIV-infected patients.Methods:APOL1 regulatory region and exon 7 were detected in renal biopsy tissues from eight HIV-infected patients with nephropathy. Thereby the APOL1 mutation was studied and its correlation with HIV infection and comorbid nephropathy was analyzed.Results:Four patients had A (-565) G mutation in APOL1 regulatory region, two had mutations at T (-1157) C, G (-1024) T and A (-765) C in APOL1 regulatory region, thre had mutations at G496A, C702A, G732A, G812A and G1008A in the exon 7 of APOL1.Conclusion:The HIV-infected patients with nephropathy in our hospital did not show G1 and G2 mutations of APOL1 gene as seen in HIV-associated nephropathy; all of the eight patients presented other types of mutation instead. The relationship between these mutations and specific pathology remains to be further studied.