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对雄性18月、25月、28月及31月龄大鼠肝脏超微结构的加龄变化进行了透射电镜的观察.发现从25月龄开始肝细胞核有的出现异染色质增多、边集,粗面内质网逐渐减少.线粒体基质深浅不一,凡基质变深者其嵴亦由板状变为泡状,最深者嵴消失.在有脂肪变性的肝细胞,其线粒体大小悬殊,形态多样,基质增深,嵴多变为泡样;内质网消失.胆小管内与窦周隙中的微绒毛减少,而窦周隙中的胶原原纤维则增多.31月龄大鼠除上述现象外,窦周隙中不但微绒毛消失,而且内皮细胞结构不清,在其外与肝细胞膜的窦周隙面均出现不规则的基膜样结构.
Transmission electron microscopy was used to observe the age-related changes of liver ultrastructure in male rats in 18 months, 25 months, 28 months and 31 months.It was found that heterochromatin appeared in liver nuclei from 25 months old, Rough endoplasmic reticulum gradually decreased mitochondrial matrix varies in depth, where the matrix becomes darker, its crest from plate to bubble, the deepest disappear ridges in fatty degeneration of hepatocytes, the mitochondrial size disparity, the shape and diversity , The matrix deepened, the crest became vacuolar, the endoplasmic reticulum disappeared, the microvilli in the bile ducts and the sinus space were decreased, but the collagen fibrils in the sinus space were increased.31 Months old rats except the above phenomenon In addition, not only the microvilli disappeared but also the endothelial cell structure was unclear, and the irregular basement membrane-like structures appeared in the sinus gap surface of the liver cell membrane.