自杀基因治疗是将来自病毒或细菌的自杀基因转染肿瘤细胞、编码特定的酶类,使无毒性的前体药物转化为细胞毒性代谢产物,从而导致肿瘤细胞死亡。利用放射性核素标记的探针可以显示自杀基因在体内的生物学特性,起到基因治疗的监测作用,其中研究最多的是单纯疱疹病毒胸苷激酶自杀基因显像。 Suicide gene therapy transports suicide genes from viruses or bacteria to tumor cells, codes for specific enzymes, and converts nontoxic prodrugs into cytotoxic metabolites, leading to the death of tumor cells. The use of radionuclide-labeled probes can show the biological characteristics of suicide genes in vivo and play a role in the monitoring of gene therapy. Among them, the most studied is the herpes simplex virus thymidine kinase suicide gene imaging.