染色体非整倍体异常是指细胞中个别染色体的增多或减少形成的染色体数目异常。产前诊断中最常见的胎儿非整倍体异常有21-三体、13-三体、18-三体以及性染色体综合征等。染色体整倍体改变多导致流产,而非整倍体改变可以出生能存活的出生缺陷儿。因此,检测胎儿非整倍体异常是许多孕妇接受产前诊 Chromosome aneuploidy abnormalities refers to the cells in an individual chromosome increase or decrease the number of chromosome formation abnormalities. Prenatal diagnosis of the most common fetal aneuploidy abnormal 21-trisomy, 13-trisomy, 18-trisomy and sex chromosome syndrome. Chromosome euploid change more lead to abortion, aneuploidy changes can be born to survive birth defects. Therefore, testing for fetal aneuploidy abnormalities is prenatal diagnosis of many pregnant women