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用吡喹酮治疗44例晚期血吸虫病人.每个病人均在治疗前和治疗后3个月2次采血检测其外周血T淋巴细胞亚群、血清肿瘤坏死因子(TNF)、羟脯氨酸(HYP)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)等,发现晚期血吸虫病人抗虫治疗后与治疗前比较:CD_4~+T细胞百分比增高,CD_8~+T细胞百分比下降,CD_4~+/CD_8~+比值增高(P值均<0.01),TNF活性降低(P<0.05),NAG和NYP的含量增高(P值均<0.05).提示:晚期血吸虫病人抗虫治疗后,虽不能使肝纤维化指标改善,但能改善细胞免疫功能,减轻肝脏的炎症反应.
Forty-four patients with advanced schistosomiasis were treated with praziquantel, and each patient was tested for blood T lymphocyte subsets, serum tumor necrosis factor (TNF), hydroxyproline HYP), N-acetyl-β-D-glucosaminidase (NAG). The results showed that the percentage of CD_4 ~ + T cells, the percentage of CD_8 ~ + T cells and the percentage of CD_4 ~ (P <0.01), TNF activity decreased (P <0.05), NAG and NYP contents increased (P <0.05) .This indicated that after the treatment of advanced schistosomiasis patients, The indicators of liver fibrosis improve, but can improve cellular immune function and reduce the liver’s inflammatory response.