目前卵巢癌的临床治疗主要采用手术切除联合术后化疗,但绝大多数晚期患者会在5年内复发,或发展为化疗耐药,其5年生存率50%,这已成为困扰妇产科医师的一大难题。卵巢癌化疗耐药的发生机制一直不能明确,为进一步治疗带来障碍,在此,我们将从细胞的膜、浆及核三方面对近期耐药机制 The current clinical treatment of ovarian cancer with surgical resection combined with postoperative chemotherapy, but the vast majority of advanced patients will relapse within 5 years, or the development of chemotherapy resistance, the 5-year survival rate of 50%, which has become a distraction for obstetricians and gynecologists A big problem The mechanism of chemoresistance in ovarian cancer has not been clear, and brings obstacles for further treatment. Here, we will analyze the recent drug resistance mechanism from three aspects of cell membrane, plasma and nuclear