目的:探讨妊娠期阻塞性睡眠呼吸障碍相关因素并观察无创正压呼吸机的治疗效果。方法:对妊娠期阻塞性睡眠呼吸障碍孕妇891例采用问卷调查的方法收集研究其一般资料、家族史、家族史睡眠情况,同时对比无创正压呼吸机治疗前后的血气指标及血压变化。结果:打鼾、睡眠中多汗、白天嗜睡、用口呼吸、夜间憋醒、夜间多尿在孕早、中、晚期发生率之间差异有统计学意义(P<0.05),均以孕晚期发生率最高;吸烟、过敏性鼻窦炎、家族打鼾史是妊娠期阻塞性睡眠呼吸障碍的危险因素。治疗后呼吸紊乱指数(AHI)、收缩压显著降低,血动脉饱和度(SaO2)显著升高,差异有统计学意义(P<0.01),舒张压治疗前后差异无统计学意义(P>0.05)。结论:对处在孕期尤其是孕晚期的女性,当出现打鼾、睡眠中多汗、白天嗜睡等症状时应引起重视,对于高危因素孕妇应加以避免和预防;无创正压呼吸机对于妊娠期阻塞性睡眠呼吸障碍者有良好的治疗作用,有助于提高母婴保健水平。 Objective: To investigate the related factors of obstructive sleep apnea during pregnancy and to observe the therapeutic effect of non-invasive positive pressure ventilator. Methods: 891 pregnant women with obstructive sleep apnea (COPD) during pregnancy were recruited to study the general data, family history and family history of sleep condition. The blood gas indexes and blood pressure before and after noninvasive positive pressure ventilator were compared with each other. Results: There were significant differences in the incidence of snoring, hyperhidrosis during sleep, daytime sleepiness, mouth breathing, nighttime arousal and nocturnal polyuria in the early, middle and late stages of pregnancy (P <0.05), both of which occurred in the third trimester of pregnancy The highest rate; smoking, allergic sinusitis, family history of snoring is a risk factor for obstructive sleep apnea during pregnancy. After treatment, the respiratory disturbance index (AHI), systolic blood pressure (SBP) and SaO2 were significantly increased (P <0.01), while there was no significant difference between before and after diastolic blood pressure treatment (P> 0.05) . Conclusion: For pregnant women, especially in the third trimester, attention should be paid to snoring, sleep sweating, daytime drowsiness and other symptoms. Pregnant women at high risk should be avoided and prevented. Noninvasive positive pressure ventilator can block the pregnancy Sleep apnea has a good therapeutic effect, helping to improve maternal and child health.