A facile one-pot synthesis of 2-aminothiazoles has been carried in PEG-400 as a greener medium at room temperature.This method avoids the use of lachrymatric a-bromoketones as well as the volatile,toxic organic solvents. A facile one-pot synthesis of 2-aminothiazoles has been carried in PEG-400 as a greener medium at room temperature. This method avoids the use of lachrymatric a-bromoketones as well as the volatile, toxic organic solvents.