目的:探讨侵袭性真菌性鼻窦炎(IFRS)的临床特点、治疗及预后。方法:5例IFRS患者,其中糖尿病患者4例,白血病化疗后患者1例。均经手术及抗真菌药物治疗。结果:术后随访1~3年,获得临床治愈3例,复发后死亡1例,病情未得到控制死亡1例。结论:IFRS的诊断及治疗需多方面综合考虑,在手术治疗的基础上行抗真菌治疗及内科治疗,可提高治愈率。 Objective: To investigate the clinical features, treatment and prognosis of invasive fungal sinusitis (IFRS). Methods: Five IFRS patients, including 4 diabetic patients and 1 leukemia patients after chemotherapy. Both by surgery and antifungal medication. Results: All cases were followed up for 1 to 3 years, 3 cases were clinically cured, 1 case died of recurrence and 1 case was uncontrolled. Conclusion: The diagnosis and treatment of IFRS need to be comprehensively considered in many aspects. Antifungal therapy and medical treatment based on the surgical treatment can improve the cure rate.