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目的了解艾滋病(acquired immunodeficiency syndrome,AIDS)患者经高效抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)后体脂肪的代谢情况。方法采用生物电阻抗法对99例经HAART治疗的AIDS患者进行体成分定量测定,用偏相关分析了解总体脂肪量与各部位脂肪量的关系,通过建立多重线性回归方程对脂肪量进行预测。结果男女患者的总脂肪量、皮下、躯干和四肢脂肪含量差异均有统计学意义(均有P<0.05)。偏相关分析显示,AIDS患者的总脂肪量与内脏脂肪量、皮下脂肪量及右上肢脂肪量均呈正相关(均有P<0.05)。多重线性回归分析结果显示,总脂肪量与皮下脂肪量、内脏脂肪量及体重关系密切。结论本研究获得了广西AIDS患者体脂肪的基线资料,可为开展AIDS病人脂代谢的防控等提供科学依据。
Objective To understand the metabolism of body fat after highly active antiretroviral therapy (HAART) in patients with acquired immunodeficiency syndrome (AIDS). Methods The bioelectrical impedance method was used to determine the body composition of 99 AIDS patients who were treated with HAART. The partial correlation analysis was used to understand the relationship between the total fat mass and fat mass at each site. The multiple linear regression equation was used to predict the fat mass. Results The total fat mass, the fat content of the subcutaneous, trunk and extremities of the male and female patients were significantly different (all P <0.05). Partial correlation analysis showed that the total fat mass of AIDS patients was positively correlated with visceral fat mass, subcutaneous fat mass and right upper limb fat mass (all P <0.05). Multiple linear regression analysis showed that the total amount of fat and subcutaneous fat, visceral fat mass and body weight are closely related. Conclusion This study obtained the baseline data of body fat in AIDS patients in Guangxi and provided a scientific basis for the prevention and control of lipid metabolism in AIDS patients.