本文报告9例骨髓增生异常综合症(MDS)患者骨髓标本的电镜观察结果。患者男性8例,女性1例,年龄24～61岁。病程10多天至2年,既往无化疗或放疗史。按FAB标准诊断及分型,包括难治性贫血(RA)4例,原始细胞过多性难治性贫血(RAEB)5例。标本经常规方法制成超薄切片。 RA和RAEB患者骨髓病变基本一致,三个血细胞系都有部分细胞受累,表现为病态造血。幼红细胞常出现核浆发育不平衡,以及核的各种异常,如外形不整、分叶;核裂、核泡;双核、芽生现象;染色质限局性消失。凝聚及溶解;最终核固缩、破碎或全部溶解。胞浆经常含较多膜性细胞器,如成群的小泡、次级溶酶体或来源不明的膜结构等(图1～2)。本组中7例见到巨核细胞,其 This article reports the results of electron microscopy of bone marrow specimens from 9 patients with myelodysplastic syndrome (MDS). There were 8 males and 1 females, aged from 24 to 61 years. Course of more than 10 days to 2 years, no history of chemotherapy or radiotherapy. According to FAB standard diagnosis and classification, including 4 cases of refractory anemia (RA), 5 cases of primitive refractory anemia (RAEB). Specimens are conventionally made into ultrathin sections. Bone marrow lesions were basically the same in RA and RAEB patients, and some of the three blood cell lines were involved in the disease, showing pathological hematopoiesis. Infant erythrocytes often appear imbalance of nuclear plasma development, as well as a variety of nuclear anomalies, such as irregular shape, lobulation; nuclear cleft, nuclear bubble; binuclear, budding phenomenon; chromatin limits disappear. Agglomeration and dissolution; the final nuclear shrinkage, broken or completely dissolved. Cytoplasm often contains more membranous organelles, such as clusters of vesicles, secondary lysosomes or unknown membrane structure (Figure 1 ~ 2). Seven cases in this group to see megakaryocytes, which