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作者于1983～1991年观察17例播散性疱疹感染(GHI)患者,其中男8例,女9例,年龄24～74岁,病程6天至6个月。全部患者死亡,大多数在死后才确诊。对患者除进行神经学检查外,还进行荧光抗体和酶免疫法等检验:9例在脑脊液和血液中检出单纯疱疹病毒(HSV)抗体,12例在脑切片中发现HSV抗原。7/9例生前确定HSV感染的特异性标志;8/12例在组织切片中发现HSV抗原;在全组17例中均发现疱疹感染(HI)的形态学特征。中枢神经系统(CNS)组织学标本采用神经组织染色法处理。 全组患者死亡前的伴随病:糖尿病(4例中2例并发糖尿病肾病和缺血性卒中),慢性炎症性疾病(肺炎1例和肾盂肾炎3例)。阑尾炎、痔、胃溃疡和子宫切除术(各1例)患者在紧接手术后发生HI。1例女性患者曾患慢性淋巴性白血病。
The authors observed 17 cases of GHI in 1983-1991, including 8 males and 9 females, aged from 24 to 74 years with a duration of 6 to 6 months. All patients died, most confirmed after death. In addition to neurological examination of patients, but also fluorescent antibody and enzyme immunoassay tests: 9 cases of herpes simplex virus (HSV) antibodies were detected in cerebrospinal fluid and blood, 12 cases of HSV antigen found in brain sections. Specific markers of HSV infection were confirmed in 7/9 prenatal cases; HSV antigen was found in 8/12 cases in histological sections; and morphological features of herpes infection (HI) were found in all 17 cases. Central nervous system (CNS) histological specimens were treated with nerve tissue staining. Concomitants before death in all patients: diabetes mellitus (2 in 4 cases with diabetic nephropathy and ischemic stroke), chronic inflammatory diseases (1 in pneumonia and 3 in pyelonephritis). Patients with appendicitis, hemorrhoids, gastric ulcer and hysterectomy (1 in each case) developed HI immediately following the operation. One female patient had chronic lymphocytic leukemia.