通过复制大鼠甲状腺功能低下和亢进的动物模型,以放射免疫测定的方法,观察了此两种情况下下丘脑、纹状体、大脑皮质等脑区及整个垂体亮-脑啡肽样免疫活性物质(Ir-LEK)含量的改变。结果表明,此两种情况下,脑及垂体Ir-LEK含量都发生了明显的变化。甲低组下丘腩、大脑皮质及垂体Ir-LEK较正常对照组明显升高,相反,甲亢组下丘、大脑皮质较正常显著减少。 By replicating the animal model of hypothyroidism and hyperthyroidism in rats, radioimmunoassay methods were used to observe the light-enkephalin-like immunoreactivity in hypothalamus, striatum, cerebral cortex, and the entire pituitary gland in both cases. Changes in the content of the substance (Ir-LEK). The results showed that both Ir-LEK levels in the brain and pituitary were significantly changed in both cases. The hypothalamus, cerebral cortex and pituitary Ir-LEK in the hypothyroidism group were significantly higher than those in the normal control group. On the contrary, the hypothyroid and cerebral cortex in the hyperthyroidism group were significantly lower than normal.