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充血性心力衰竭（C H F）是一种复杂的临床症状群，为各种心脏病的严重阶段，其发病率高，它的发生发展过程，除了心肌细胞肥大、凋亡、细胞外基质变化导致心肌重塑外，某些相关细胞因子亦参与了心衰的进程，并起到推波助澜的作用。越来越多的证据表明细胞因子（主要有：肿瘤坏死因子-a、白介素-6）是充血性心力衰竭的病理生理和发病机制中的重要因子，它通过介导左室重构、使 B-2肾上腺素受体失耦联、降低心肌收缩力等作用引发或加重心衰。本文主要探讨心力衰竭时免疫系统中细胞因子的变化。“,” CHF Is a complex of clinical symptoms with high incidence,which is serious stage of al kinds of heart disease. It happened in the development process, in addition to myocardial cel hypertrophy, apoptosis, extracel ular matrix cardiac remodeling the change, some related cel factors also participated in the heart failure process, and play a important role. More and more evidence that cel factor is important factor for physiological and pathological on mechanism of congestive heart failure. It is through left ventricular remodeling, make B-2 adrenaline receptor coupling, reduce the lost force of cardiac muscle systole effect such as cause or worsen heart failure. This paper mainly discusses the change of immune system cel s in heart failure.