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Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare,and prolymphocytic transformation of SLVL is rarer.At present,only one case of SLVL with t(8;14)(q24;q32) translocation has been reported.In this study,we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation.A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes ＞ 200 × 109/L).The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli.The immunophenotypes showed CD19+,CD20+,HLA-DR+,CD22+,CD5+,Kappa+,CD25dim,CD71dim,Lambda-,CD7-,CD10,CD23-,CD34-,CD33-,CD13-,CD14-,CD117-,CD64-,CD103-,and CD11c.The karyotype showed complex abnormality:46XX,+ 3,-10,t(8;14)(q24;q32)[11]/46XX[9].The cytoplasmic projection,immunological characteristics,and trisomy 3 chromosome abnormality supported the diagnosis of SLVL.However,the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation,probably as a result of t(8,14) chromosome translocation.In this report,we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation,which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.