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目的检测Spindlin1在不同级别宫颈病变组织中的表达;分析Spindlin1的表达与不同级别宫颈病变及宫颈鳞状细胞癌(cervical squamous cell carcinoma,SCC)临床病理指标的关系,探讨其在SCC发生发展中的意义。方法采用免疫组化法检测105例不同级别宫颈病变组织中Spindlin1的表达。结果Spindlin1表达于细胞核,在正常宫颈鳞状上皮表达为13.3%,宫颈上皮内瘤变(cervical intraepithelial neoplasias,CIN)I级表达为46.7%,CINⅡ~Ⅲ级表达为56.7%、SCC表达为75.6%,阳性表达率随宫颈病变程度的加重逐步上升,其表达强度随宫颈病变程度的加重而增强(P<0.05)。Spindlin1的表达与SCC临床病理指标之间无关联(P>0.05)。结论 Spindlin1随宫颈病变程度的加重表达升高,在SCC中高表达,可能与SCC的发生有关,但与SCC的转移、复发无关。
Objective To detect the expression of Spindlin1 in cervical lesions of different grades and analyze the relationship between the expression of Spindlin1 and different grades of cervical lesions and clinicopathological features of cervical squamous cell carcinoma (SCC) significance. Methods Immunohistochemistry was used to detect the expression of Spindlin1 in 105 cases of cervical lesions. Results The expression of Spindlin1 in the nucleus was 13.3% in normal cervical squamous epithelium, 46.7% in cervical intraepithelial neoplasias (CIN), 56.7% in CINⅡ ~ Ⅲ and 75.6% in SCIN , The positive expression rate gradually increased with the severity of cervical lesions, and its expression intensity increased with the severity of cervical lesions (P <0.05). There was no correlation between the expression of Spindlin1 and clinicopathological features of SCC (P> 0.05). Conclusion The expression of Spindlin1 is increased with the severity of cervical lesions. The high expression of Spindlin1 in SCC may be related to the occurrence of SCC but not to the metastasis and recurrence of SCC.