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通过对蛋白质溶液在中空纤维亲和膜中流动状况和吸附反应的分析，建立了中空纤维亲和膜蛋白质吸附的动力学表达式．以人γ─免疫球蛋白在A蛋白为配基的亲和膜上的吸附为例，分析了所有亲和吸附位点的反应速度常数都一致的均一吸附和存在两种亲和吸附位点、反应常数不同的非均一吸附两种情况并建立了相应的模型．用有限差分法获得了吸附透过曲线并与实验结果进行了对照．结果表明非均一吸附模型的预测与实验值更为接近．
The kinetic expression of protein adsorption on hollow fiber affinity membrane was established by analyzing the flow of protein solution in the affinity membrane of hollow fiber and the adsorption reaction. Taking the adsorption of human γ-immunoglobulin on the affinity membrane of protein A as an example, we analyzed the uniform adsorption and existence of two affinity adsorption sites for all the affinity adsorption sites, Reaction constant different heterogeneous adsorption two cases and established the corresponding model. Adsorption curves were obtained by finite difference method and compared with the experimental results. The results show that the heterogeneous adsorption model predictions and experimental values are more similar.